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Evidence generation, commissioning and adoption are frequently treated as separate challenges rather than part of a single journey

[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency

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By one recent estimate, although 50 percent of the drugs tested in animals do go on to be tested in humans, only 5 percent are ultimately approved for use by people