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Although these molecules do not cross the blood-brain barrier (BBB), they exert their action through the circumventricular organs and several select sites adjacent to the ventricles [50]

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Curiously, in 1984 it was recognized that the actual reasons for the electron density missing from a protein structure can be very different (Garner et al., 1998)), i.e., the wholesale movement of a structured domain facilitated by a flexible hinge

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