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The two ingredients work through different mechanisms with very little overlap

5-Amino-1MQ 5 mg is supplied as a high-purity research compound , designed to provide consistent and reliable performance across experimental models investigating NNMT-related pathways

Changes in thyroid function tests are generally not observed, despite theoretical concerns based on animal studies showing thyroid C-cell effects

As summarized in the same 2013 review, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, even as the safety and tolerability picture held [7]