The exact cause is unknown, but researchers believe that a combination of genetic susceptibility and environmental triggers may play a role
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In the context of tumor immune microenvironment remodeling, the SSP induces an immunosuppressive phenotype, promotes M2-type macrophage polarization, sustains high PD-L1 expression, impairs the cytotoxic function of CD8 + T cells, and compromises the therapeutic efficacy of CAR-T cells
Research has demonstrated that calcium D-glucarate supplementation serves as an effective slow-release source of glucuronolactone, which appears to block the actions of the enzyme beta-glucuronidase