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This was the case in clinical trials, where participants had their dose adjusted until they reached 2.4 mg once weekly

Unfortunately, benefits in slowing progression of CKD were not demonstrated in this study, so the results with weekly injectable semaglutide seen in FLOW cannot be extrapolated to oral semaglutide as a result of this study, which was undertaken in a different population with a different primary outcome

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Two studies from Denmark [32, 36], using a grace period of 90 days (as was done in our main analyses), reported that approximately 20% of both GLP-1 receptor agonist users [32, 36] and SGLT2 inhibitor users [32] had discontinued treatment within 1 year of treatment initiation

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