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In the vascular epithelial cells, the key effectors are Rac1 and RhoA protein in the mevalonate pathway, Rac1 can maintain the stability of the cytoskeleton and promote cell migration via regulating NOX, and RhoA protein can keep from the ubiquitin degradation of p27, inhibit cell cycle progression

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Phelan McDermid syndrome (PMS) and HelsmoortelVan der Aa syndrome (HVDAS) PMS results from the loss of one functional copy of the SHANK3 gene of chromosome 22q13 [337]

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