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This delayed movement of food from stomach to intestines creates the satiety effect that makes GLP-1 therapy effective for weight loss, but the same mechanism can reduce bowel motility

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17(12):e1003228 Doumouras AG, Hong D, Lee Y, Tarride JE, Paterson JM, Anvari M (2020) Association between bariatric surgery and all-cause mortality: a population-based matched cohort study in a universal health care system

MOTS-c's AMPK activation aligns with the body's metabolic circadian rhythm, which peaks in the morning and early afternoon

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