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Nevins and Thurmond demonstrated that cells formed filamentous F-actin associated with the t-SNARE proteins syntaxin 1A and SNAP-25 in response to glucose, slowing insulin release 8 , a finding later confirmed by Quinault et al

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Tirzepatide is a GLP-1 receptor agonist as well, but it also agonizes (initiates or encourages) the hormone GIP