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The catalytic subunit of GCL is subject to competitive feedback inhibition by glutathione, thus preventing an excess of glutathione production (Richman and Meister 1975)

Thus, in addition to simply acting as a sedative agent, dexmedetomidine seems to treat the underlying pathophysiology (serotonin excess)

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Age-related gene expression patterns reverse

Consider B 12 supplementation without testing in asymptomatic patients with risk factors for B 12 deficiency (see Table 1: Patient Risk Factors Associated with B 12 Deficiency)