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Due to their expression of oncogenes, cancer cells are more susceptible to the effects of fasting and CR than are normal cells, an effect termed differential stress resistance

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This shows how NO and ROS signaling from stromal cells creates a pro-tumor environment, reinforcing the toxohormone concept, where signals from one cell type promote cancer growth in another (129, 132)

For both males and females, over 90% of test results fell within the established reference intervals, demonstrating that the intervals determined in this study are appropriate for clinical use (Table IV)