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The antioxidant mechanism of SeNPs involves the reduction of ROS through the following reaction: Elemental selenium (Se) This study highlighted the potential of SeNPs in addressing oxidative stress-related disorders (Shanmugam et al., 2023)

Moreover, properly harnessing the Nrf2/HO-1 axis while managing its potential pro-ferroptotic risks may help maintain redox balance and curb iron overload, thereby offering an additional strategy to alleviate ferroptosis-driven damage in OA (202)

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On the other hand, the anomalous hypomethylation of the promoter regions of long interspersed element-1 (LINE-1) (57) and syncytin-1 (58) has been linked to the malignant conversion of endometriosis