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Research suggests melanocortin signaling helps modulate the transition between wakefulness and sleep, though the precise mechanism is complex and bidirectional

doi: 10.15835/NBHA52414070 269 SunkarR.BartelsD.KirchH

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Although the STAT family members are activated via various cytokines, STAT2 and STAT6 are predominantly activated by IFN- and IL-4, respectively (101)