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The S 1 pocket typically accommodates a substituted aromatic ring or a substituted saturated heterocycle, with the ligands main amine forming a hydrogen bond with Glu-205/206 (82)

The atopic dermatitis flare resolved, and post-inflammatory hyperpigmentation improved (Figure 4)

Solomons NW, Rosenberg IH, Sandstead HH, Vo-Khactu KP

Electrophysiological signals were captured using an Axopatch 700B amplifier (Molecular Devices, San Jose, CA, USA) and subsequently analyzed offline on a PC using pCLAMP software (Clampfit 10.4, Molecular Devices)