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This finding was confirmed in two studies using murine CD4 + T-cells, which suggested that D3 mediates the increase in T h 1-differentiation by reducing ERK phosphorylation, while a D3-mediated reduction in cAMP levels also increased CD4 + T-cell activity (Gonzlez et al., 2013

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[5] Both are biologically active, but only l-carnitine naturally occurs in animals, and d-carnitine is toxic as it inhibits the activity of the l-form

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