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In the MitoPark mouse, one of the few preclinical models of progressive PD, a clinically translatable dose of exendin-4 reduced the rate of dopaminergic neuronal loss and accompanying motor dysfunction (150), and mitigated mitochondrial dysfunction and loss (151)

Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes