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The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine

118 Reisi et al reported that both presynaptic and postsynaptic components are involved in diabetes-induced damage to synaptic plasticity

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The primary equation for this process is $$ 2GSH + H_2O_2 \rightarrow GSSG + 2H_2O $$, where two molecules of reduced glutathione (GSH) reduce hydrogen peroxide (HO) to water, producing oxidized glutathione disulfide (GSSG)