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Despite the progress, unmet clinical needs remain, including safe dose escalation in bulky, hypoxic, or radioresistant tumors, effective modulation of the immunosuppressive tumor microenvironment, and integration of personalized, multi-modal therapies

Ferrous Fumarate: Gastrointestinal disturbances (anorexia, nausea, diarrhea, constipation, heartburn, and vomiting) occur occasionally, but are usually mild and may subside with continuation of therapy