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These symptoms may indicate rhabdomyolysis or another serious condition requiring immediate investigation

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After 30 days on the 3 mg dosage, your healthcare provider may have you increase your dosage to 7 mg

Several preclinical and clinical studies have demonstrated that CSF1R inhibitors, including small-molecule tyrosine kinase inhibitors (e.g., PLX3397, GW2580, and Ki20227) and monoclonal antibodies targeting CSF1R or its ligand CSF1, can effectively deplete or reprogram TAMs, thereby improving tumor immune contexture and enhancing the efficacy of ICIs (161)