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Furthermore, it has been demonstrated that higher doses of NAC (18 g/d) have decreasing effects on E2 levels compared with lower doses

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Its real-world benefit is conditional strongest in vegetarians, vegans, and physically active individuals, and weak to negligible in sedentary people with already-sufficient carnitine status

From these data a Mg 2+ or Mn 2+ -dependent catalysis was concluded as also demonstrated for other members of the enzyme superfamily (Hurley et al., 1991