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Furthermore, icariin extracted from Epimedium can also function as a GPER agonist by activating GPER and subsequently increasing the expression of sirtuin 1 (Sirt1), thereby reducing the translocation and release of high-mobility group box 1 (HMGB1) and inhibiting inflammation to improve endothelial function in type 1 diabetic rats [193]

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4.2.1 The composition and function of the intestinal barrier The intestinal barrier consists of mucus layer, epithelial barrier, and gut vascular barrier, behaving as a coordinated and multilayered network that protects host physiology from external insults and regulates several gut functions

Reduced tolerance is nearly universal among GLP-1 users