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The core lies in the Proxylane anti-aging mechanism : it mimics xylose to stimulate glycosaminoglycans (GAGs) synthesis, thereby Repairing the basement membrane and reinforcing the DEJ junction

This observation is consistent with that observed in clinical PCOS patients [49, 50]

Insoluble material was removed by centrifugation at 65,000 g for 40 min and the solubilized complex was incubated overnight at 4 C with pre-equilibrated Nickel resin (Ni Smart Beads 6FF, SMART Lifesciences) containing 10 mM imidazole