Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations 2-OGC: 2-oxoglutarate AD: Alzheimers disease DIC: Dicarboxylate DISC: Death-inducing signaling complex ER: Endoplasmic reticulum GCL: Glutamate-cysteine ligase GGT: -glutamyl transferase GR: Glutathione reductase Grx: Glutaredoxin GS: GSH synthetase GSH: Glutathione GSH: Reduced glutathione GSSG: Oxidized glutathione GSTs: Glutathione S-transferases H 2 O 2 : Hydrogen peroxide HCC: Hepatocellular carcinoma HCV: Hepatitis C virus HO : Hydroxyl radical mGSH: Mitochondrial GSH MIM: Mitochondrial inner membrane MIS: Mitochondrial intermembrane space MOM: Mitochondrial outer membrane NAPQI: N-acetyl-p-quinoneimine NMDA: N-methyl-D-aspartate O 2 : Superoxide anion radical PD: Parkinsons disease RNS: Reactive nitrogen species ROS: Reactive oxygen species SAM: S-adenosyl-l-methionine Trxs: Thioredoxins References Anasagasti MJ, Martin JJ, Mendoza L, Obrador E, Estrela JM, McCuskey RS, Vidal-Vanaclocha F (1998) Glutathione protects metastatic melanoma cells against oxidative stress in the murine hepatic microvasculature
Current nanocatalytic therapies are limited to catalyzing the breakdown of ROS and are unable to target the underlying source of ROS generation, which is mitochondrial dysfunction
Johanns et al., 2016)
Ann N Y Acad Sci 1033 : 108116 Kira Y, Nishikawa M, Ochi A, Sato E, Inoue M 2006 l-carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis
Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
