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Nausea affects up to 40-45% of participants at higher doses

However, persistent severe heartburn lasting more than 4 weeks, pain when swallowing, vomiting blood, or black stools warrant immediate medical attention, as these may indicate more serious gastric complications

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Subsequently, oral formulations and once weekly injections were developed in the 2010s and liraglutide was the first GLP-1 receptor agonist approved for the treatment of obesity in 2014