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Specifically, thiamine is important for glucose metabolism [51] and type 2 diabetics have been observed to have lower-than-average thiamine levels, suggesting that some degree of thiamine deficiency may play a role in the onset of diabetes

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Indeed, differences in segregation of activated GLP-1Rs into these membrane rafts are an important feature of biased agonist action (Buenaventura et al ., 2019)

Cardiovascular and kidney outcomes are harder to prove and more clinically important