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This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

It can result from chronic alcohol abuse, viral hepatitis, and other liver diseases

Slaven Gojkovic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia

Neuropathic pain, stemming from lesions or maladies afflicting the somatosensory nervous system, precipitates aberrant sensory processing within the brain and spinal cord

R., Beaudet, A