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123 The native glucagon peptide stimulates cAMP production, and elevated cAMP levels in rat hepatocytes indirectly reduce CYP2C11 expression

According to recent complaints, patients developed non arteritic anterior ischemic optic neuropathy, or NAION, after using the semaglutide based medications

This class of drugs is known as GLP-1s

For the expanded semaglutide clinical programs (SELECT, SOUL, FLOW trials), immunogenicity monitoring data confirmed the consistent, low immunogenicity profile across indications and formulations

Although the number of patients studied is limited and the results cannot be considered generalizable to people without obesity. How does this work fit with existing evidence