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Depletion of NADPH impairs NO synthesis and lowers glutathione levels, causing an overproduction of oxygen free radicals, which compromises endothelial cell function in blood vessels (Odai et al., 2019

It has more to do with brain signals associated with GLP-1 use than any active dysfunction

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And if you're dealing with diarrhea or vomiting on top of everything else, hydration becomes extra importantaim for at least eight glasses of water daily, because dehydration is basically an energy vampire