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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Kanehisa M., Sato Y., Furumichi M., Morishima K., Tanabe M

These include nerve damage, brain function decline, and even dementia

NoGLP-1 and GIP receptor activation does not directly affect sleep architecture or melatonin secretion

Given that the traditional approach to weight management and high BMI often results in weight cycling and increased weight stigma, I agree with many researchers that a weight-inclusive approach (including physical activity independent of intentional weight loss) is preferable

In particular, lysosomal cholesterol accumulation may predispose to APAP hepatotoxicity by a dual mechanism involving the impairment of mitophagy in hepatocytes and the disruption of TLR9 trafficking in LSEC