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Supplementation of -linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes

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One intriguing recent discovery is that gut microbes can produce small amounts of ammonia and other compounds that affect brain metabolism: a 2025 study showed that manipulating the gut microbiome altered brain amino acid levels and stress susceptibility in mice, partly via microbe-derived ammonia affecting neurotransmitter cycling [88]

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Both groups experienced a decrease in body weight and BMI, though without significant inter-group differences