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In recent years, GLP-1 RA use has expanded to people with lower A1C and BMI levels at the time of prescription initiation and surged in popularity among individuals with both T2D and overweight/obesity (Gratzl et al., 2024)

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In the context of chronic weight management, dose increases may be warranted when weight loss is insufficient or plateaus before reaching clinically meaningful targets

Carnitine is an essential metabolite for fatty acid oxidation, as it facilitates the transport of long-chain fatty acids into mitochondria through the carnitine shuttle system, which involves carnitine palmitoyltransferase 1 (CPT1), carnitine-acylcarnitine translocase (CACT), and CPT2