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In GHK-Cu, it denotes that the tripeptide glycyl-L-histidyl-L-lysine (GHK) is bound to a copper(II) ion, forming the copper-peptide complex researchers study the Cu specifically distinguishes the copper-bound complex from the standalone GHK peptide, which research has shown behaves differently without the copper ion attached

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Clinical data highlights its role in Phase II liver detoxification, binding to toxins so they can be excreted

Copper Safety Concerns about copper toxicity from GHK-Cu are understandable but largely unwarranted at recommended doses

On the other hand, ACSL4 and TFR1 are downregulated, which inhibits lipid peroxidation and decreases the levels of intracellular iron