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The data reinforce that GLP-1RAs exert cardiovascular benefit through multiple mechanisms beyond fat reduction, with approximately two-thirds of the effect unexplained by changes in body composition

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If thats not possible, Shahs general recommendation to his GLP-1 patients is to do resistance exercises three times per week and aerobic exercise another three days

The investigators compared people who had used these drugs with clinically similar patients who had not received them, then assessed whether either group was more or less likely to develop substance use disorders