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Based on the promising preclinical data, Bunce conducted a small, double-blind, placebo-controlled trial funded by the National Institute on Drug Abuse and Novo Nordisk, the company that makes Ozempic and Wegovy

Managing Constipation and Upset Stomach on GLP-1s GLP-1 treatments are a game-changer for patients with diabetes and those on a weight management journey

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However, timing matters: Recommended Approach: Start with a 12:12 eating window (12 hours eating, 12 hours fasting) Gradually progress to 14:10 or 16:8 if well-tolerated Ensure your eating window aligns with circadian rhythms (earlier is generally better) Important Considerations: Research shows that higher fasting GLP-1 concentrations are associated with lower carbohydrate intake, particularly simple sugars