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investigators should attend to the regulatory context, since none of the three components are approved as drugs in any major jurisdiction

Advantages: Greatest long-term weight loss (2540%) Strong improvements or resolution of diabetes and other conditions Considerations: Invasive with incisions Longer recovery (26 weeks) Higher surgical risks Requires lifelong dietary adjustments and vitamin supplementation GLP-1 Medications : Powerful, Non-Surgical Support GLP-1 receptor agonists (such as semaglutide and tirzepatide) are injectable medications that help reduce appetite, improve insulin sensitivity, and support weight loss

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A nutritional formulation for cognitive performance in mild cognitive impairment: A placebo-controlled trial with an open-label extension