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Comprehensive literature searches were performed in PubMed, Web of Science, and Google Scholar (title search only) up to January 31, 2025

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This means that the variants that bind poorly to IGFPB have a short duration of action, faster onset of action and rapid withdrawal as compared to IGF-1 [4] In a study, researchers compared the hypoglycemic effects of IGF-1 and its variant IGF-1 Des in marmosets and pigs