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Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y,

HMGB1 cytoplasmic translocation initiates inflammasome activation and release into the extracellular space, a mechanism shown to be seizure provoking [48]

We have recently reported on a new pharmacometabolomics approach in which the levels of metabolites, specifically cannabis-responsive biomarkers, in children with ASD being treated with MC shifted toward the physiologic levels detected in untreated typically developing (TD) children 14,15

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