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The bodys natural defense system against the damaging oxidants includes a protein called glutathione (GSH) (2)

Implication of processed pseudogenes derived from heme oxygenase-2 gene

The results are similar to the research work of Wang et al

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Separate studies have defined that these HO-1 hi M2-TAMs are driven by NRF2 through HIF1, p50 NF-BCSF-R1C3aR axis signaling, tend to localize to the invasive margin, and support tumor, growth, angiogenesis and EMT transition [64, 65]