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In one study, weight loss capsules containing green tea, ginger, and capsaicin (the spicy component of chili peppers) were much more effective in promoting weight loss than a placebo

amygdalina leaf extracts, oral administration of a single dose of 5,000 mg/kg did not produce any harmful symptoms or mortality in rats, indicating an LD 50 greater than 5,000 mg/kg (652)

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

In the Phase 2 trial by Jastreboff et al., 2023, the authors reported graded weight reductions of -8.7 percent (1 mg), -17.1 percent (4 mg), -22.8 percent (8 mg), and -24.2 percent (12 mg) versus -2.1 percent on placebo