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The results showed that oral semaglutide significantly reduced HbA1c levels if compared with dulaglutide ( 0.85%, 95% CI 1.25 to 0.45), exenatide [ 0.93%, 95% CI 1.32 to 0.54 (dose 10 g) and 0.89%, 95% CI 1.27 to 0.51 (dose 2 mg)], liraglutide ( 0.42%, 95% CI 0.78 to 0.05), and lixisenatide ( 1.32%, 95% CI 1.74 to 0.91) [50]

The subcellular location of apoA5 and apoC3 regulating VLDL lipidation are proposed to be the ER compartment