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In a mouse model with full-thickness articular cartilage defects created on the trochlear groove using a 26G needle, catalpol contributes to cartilage regeneration, bone structure improvement, and increased matrix anabolism by stimulating endogenous mesenchymal stem cells (MSCs) in the cartilage, thus promoting the repair of localized cartilage defects (Wu et al., 2024a)

In men, these changes may affect testosterone levels, while women might experience shifts in estrogen balance that impact arousal and satisfaction

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