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This orexigenic drive appears to be largely GH-independent, as it is observed even in models of GH-deficiency, and is accompanied by rises in leptin that likely reflect expansion of adipose depots and provide a feedback brake on further hyperphagia

Deficiency of the Circulating Insulin-like Growth Factor System Associated with Inactivation of the Acid-Labile Subunit Gene

Biochem Biophys Res Commun 291:453457

Key Findings (20-year risks in early-onset AF vs matched controls): Stroke: 6.9% | 2x higher risk Heart Failure: 6.5% | 45x higher risk Death: 7.1% | 1.4x higher risk Take-home message: Even in the absence of traditional comorbidities, early-onset AF is a marker of future cardiovascular complicationsespecially cardiomyopathy and HF

Neuroimaging and molecular work could reveal how incretins act on central and peripheral chemosensory pathways, Moser added