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In clinical trials, patients were sometimes allowed to stay at a lower dose for up to 8 weeks if needed to let side effects settle down

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Coleman and Blass (108) first identified the presence of lactic acidosis in a small set of patients in 1985, with Lombard (109) later proposing that ASD may be at least partially due to abnormal neuronal oxidative phosphorylation

Thymosin 4: Structure, Function and Biological Properties Supporting Current and Future Clinical Applications