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The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
Less weight means less mechanical pressure on joints
The clinical data tells a clear story
GLP-1 medications, originally used for those with Type 2 diabetes, have recently grown in popularity as a weight management tool with brand name drugs such as Ozempic, WeGovy and Byetta
Diabetes and neurodegenerative diseases A growing body of evidence supports the link between diabetes and an increased risk of neurodegenerative diseases such as AD and PD
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