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The septic milieu itselfcharacterized by a cytokine storm and metabolic acidosisacts as a potent upstream disruptor of copper homeostasis, priming the heart for copper-dependent injury [175]

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NAD+: an innovative alternative to conventional alcohol detox therapy Current alcohol detox programmes have a high rate of relapse, as patients find it impossible to withstand cravings, often quickly returning to past patterns of behaviour