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PMA-induced expressions of ICAM-1 and MMP-9 at the RNA and protein level in a dose-dependent manner were also observed[218]

Briefly, during phase 1, cells were grown in Iscoves Modified Dulbecco medium (IMDM) with 15% fetal bovine serum (FBS), 15% human AB serum, 10 ng/mL interleukin-3, 50 ng/mL stem cell factor and 2 IU/mL erythropoietin (Sigma-Aldrich, St

In streptozotocin-induced diabetic mice, metformin has been shown to significantly improve sperm count, testicular proliferation, and testosterone levels, which may depend on elevated leptin levels and the expression of its receptor Ob-R in the testis of mice after administration of metformin (Annie et al

Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 60 , 3844, doi: 10.1016/j.fct.2013.07.008 (2013)