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The use of peptides in knee OA is still in its exploratory stages, but so far they are receiving enthusiastic feedback from the regenerative medicine community

However, critical barriers hinder their clinical translation: (1) regulatory and scalability challenges, such as standardizing sterilization/long-term stability for liposomes/SLNs, require rigorous evaluation of immune responses (e.g., PEGylated liposomal uricase) and cost-effectiveness for advanced systems (biomimetic nanoliposomes and ethosomal gels)