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Esaki H, Tachi T, Goto C, Sugita I, Kanematsu Y, Yoshida A, Saito K, Noguchi Y, Ohno Y, Aoyama S, Yasuda M, Mizui T, Yamamura M, Teramachi H

The research on joint-specific conditions strongly favors injectable administration, particularly local injection near the affected area

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In the 3rd injection cycle, the same volume of stock solution contacts 25% more capillaries, and the drug is carried away by the systemic blood circulation faster, weakening the local targeted dissolution ability

Masuda et al., 2020), and healthy brain parenchyma has little macrophage and monocyte infiltration due to blood-brain barrier (BBB)