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Ubidecarenone enhances succinate-dependent and glycerol-3-phosphate-dependent ROS generation, mitochondrial membrane depolarization, and regulated cell death Impairments to the mitochondrial ETC, in particular the loss of efficiency in electron transfer from Complex III or mGPDH to oxygen (as reported above), can result in electron leakage and ROS generation 10
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In view of the role of Se deficiency in promoting thyroid tumorigenesis and progression, appropriate Se supplementation for differentiated thyroid cancer has been proposed to delay the disease progression and improve the prognosis (98).Kato, M
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