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This was because other GLP-1 analogues, such as dulaglutide and loxenatide, were only used in overweight/obese BMI trials

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GLP1R is also expressed in the brain where it is involved in the control of appetite

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Among these, liraglutide in the LEADER study, semaglutide in the SUSTAIN-6, albiglutide in the Harmony Outcomes, dulaglutide in the REWIND, and efpeglenatide in the AMPLITUDE-O exhibited significant beneficial effects on 3-point major adverse cardiac events (3P-MACE: death from CV disease, non-fatal myocardial infarction, and non-fatal stroke), the primary end point of each study, compared to the placebo group, respectively