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The separate, permanent BALANCE Model that would have built weight-loss GLP-1 coverage into Part D is indefinitely delayed on April 21, 2026, CMS declined to implement it in Part D for 2027 and extended the Bridge instead

Differences in individual specificity and tolerance to GLP-1 RAs may be the main reason for differences in weight loss (Ruder, 2023), with racial differences also contributing ( 4.2 Severe versus non-severe cases The most frequently reported adverse effects associated with GLP-1 RAs were gastrointestinal in nature

doi:10.1093/ajcn/77.1.189 Polonikov A

Zepbound has also been shown to improve related cardiometabolic markers, including reductions in blood pressure, cholesterol, and visceral fat in people with obesity